Mikamo Lecture : A Radical View of the 'Superfamily' of Cardiovascular Risk Factors

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概要

• 論文の詳細を見る

• Many risk factors for cardiovascular disease generate superoxide in the blood vessels and thereby impair endothelial function. To emphasize the critical role of oxygen radicals, this is a 'radical view' of those risk factors. It will be useful to organize risk factors into a 'superfamily', with consideration of mediators, mechanisms, and target organs. Studies are summarized which suggest that, in parallel with the impairment of endothelial vasomotor function, the thrombin/thrombomodulin/activated protein C anticoagulant mechanism, which requires endothelial thrombomodulin, is also impaired by atherosclerosis and improves during regression of atherosclerosis. Impairment of the anticoagulant mechanism may contribute to thrombosis in atherosclerotic arteries, and improvement of the anticoagulant mechanism during regression of atherosclerosis may reduce the risk of cardiovascular events.

• 社団法人日本循環器学会の論文
• 2003-09-20

著者

• HEISTAD Donald

  Department of Internal Medicine, University of Iowa

• Heistad Donald

  Department Of Internal Medicine And Pharmacology University Of Iowa Carver College Of Medicine

• Heistad Donald

  Departments Of Internal Medicine And Pharmacology Roy A. And Lucille J. Carver College Of Medicine U

関連論文

• Gene Transfer to Cerebral Blood Vessels : What's the Future ?
• Mikamo Lecture : A Radical View of the 'Superfamily' of Cardiovascular Risk Factors
• Novel Aspects of Oxidative Stress in Cardiovascular Diseases

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