Immobilization of Arg-Gly-Asp (RGD) Sequence in a Thermosensitive Hydrogel for Cell Delivery Using Pheochromocytoma Cells (PC12)(MEDICAL BIOTECHNOLOGY)

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概要

• 論文の詳細を見る

• A copolymer of N-isopropylacrylamide (98 mole% in the feed) and acrylic acid poly(N-iso-propylacrylamide-co-acrylic acid) [p(NiPAAm-co-AAc)], and the adhesion molecule, an Arg-Gly-Asp (RGD)-incorporated hydrogel, were used to entrap pheochromocytoma cells (PC12). In a 28-d culture period, the PC12 cells in the RGD-conjugated gel maintained higher viability and produced dopamine at constant rates, while there was lower cell viability and less dopamine secretion by PC12 cells in p(NiPAAm-co-AAc). PC12 cells cultured in the RGD-conjugated gel would constitute a potentially useful three-dimensional cell system for application in nerve regeneration.

• 社団法人日本生物工学会の論文
• 2004-06-25

著者

• PARK Keun-Hong

  Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University

• Park Keun-hong

  Department Of Biomedical Engineering Ajou University

• YUN KYUSIK

  BioElectronics Group, Devices & Materials Lab., LG Electronics Institute of Technology (LG Elite)

• Yun Kyusik

  Gachon Bionano Res. Inst. Kyungwon Univ.

関連論文

• Phenotype of Hepatocyte Spheroids in Arg-Gly-Asp (RGD) Containing a Thermo-Reversible Extracellular Matrix(Organic Chemistry)
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• Specific Interaction between Erythrocytes and a Glucose-Carrying Polymer Mediated by the Type-1 Glucose Transporter (GLUT-1) on the Cell Membrane
• Immobilization of Arg-Gly-Asp (RGD) Sequence in a Thermosensitive Hydrogel for Cell Delivery Using Pheochromocytoma Cells (PC12)(MEDICAL BIOTECHNOLOGY)
• Inducing Chondrogenic Differentiation in Injectable Hydrogels Embedded with Rabbit Chondrocytes and Growth Factor for Neocartilage Formation(CELL AND TISSUE ENGINEERING)

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