Investigating the Potential for Interaction between the Components of PM_<10>

概要

論文の詳細を見る
The adverse health effects of elevated exposures to PM_<10> (particulate matter collected through a size selective inlet with an efficiency of 50% for particles with an aerodynamic diameter of 10 μm) in relation to morbidity and mortality, especially in susceptible individuals, are now well recognised. PM_<10> consists of a variable cocktail of components differing in chemical composition and size. Epidemiological and toxicological data suggest that transition metals and ultra fine particles are both able to drive the cellular and molecular changes that underlie PM_<10>-induced inflammation and so worsen disease status. Toxicological evidence also suggest roles for the biological components of PM_<10> including volatile organic compounds (VOC's), allergens and bacterial-derived endotoxin. Many of these components, in particular transition metals, ultra fine particles, endotoxin and VOC's induce a cellular oxidative stress which initiates an intracellular signaling cascade involving the activation of phosphatase and kinase enzymes as well as transcription factors such as nuclear factor kappa B. Activation of these signaling mechanisms results in an increase in the expression of proinflammatory mediators, and hence enhanced inflammation. Given that many of the components of PM_<10> stimulate similar or even identical intracellular signaling pathways, it is conceivable that this will result in synergistic or additive interactions so that the biological response induced by PM_<10> exposure is a response to the composition rather than the mass alone. A small number of studies suggest that synergistic interactions occur between ultra fine particles and transition metals, between particles and allergens, and between particles and VOC's. Elucidation of the consequences of interaction between the components of PM_<10> in relation to their biological activity implies huge consequences for the methods used to monitor and to legislate pollution exposure in the future, and may drive a move from mass based measurements to composition.
日本衛生学会の論文

Investigating the Potential for Interaction between the Components of PM_<10>

スポンサーリンク

概要

著者

関連論文

スポンサーリンク