心房筋の興奮性に関する実験的研究 : 迷走神経と強心配糖体の心房筋興奮性に及ぼす影響と相互関係に就いて
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It is well known that vagus nerves have some effects of occurrence and disappearance of arrhythmia, and also that cardiac glycoside with antiarrhythmic action has the references to the action of vagus nerves. Mechanism of the antiarrhythmic action of cardiac glycoside has been clarified. Some points, however, are yet unknown. In the present experiment, the effects of vagal stimulation and cardiac glycoside on excitability were studied on the canine heart in situ. Method : Twenty-nine adult mongrel dogs were used for this experiment. Dogs were anesthetized with intravenous administration of pentobarbital sodium, 30 to 40 mg per kg of body weight. Under artificial respiration, the chest of dog was opened. Bipolar electrodes used for recording were inserted into the endocardium of the atrium and the ventricle. The electrode was consisted of two insulated copper wires of 80μ in each diameter. Those bare tips were sharply bent as fish hook. Unipolar electrode was used for stimulating. In order to measure the absolute refractory period (A.R.P.), the total refractory period (T.R.P.) and the diastolic threshold (D.T,), the heart was artificially driven at constant frequency of 160〜250 cycles per minute. When the knob switch was pushed down, the first action potential resulting from the heart activation was introduced to the stimulator as a triggering signal. The stimulator for evocation of extrasystole was arranged to deliver a square pulse with a desired delay from the onset of the triggering signal. The test stimulus was given unipolarly through the cathodal terminal in the atrium. The distant electrode placed on the right hind leg served as the anode. The intensity of test stimulus was varied within the range from the diastolic threshold to the intensity of about 40 times as large as the diastolic threshold. For the recording of electrograms, the cathode ray oscilloscope and long recording camera were used. The film speed was 20 to 50cm per second. A.R.P., T.R.P. and D.T. were calculated by the strength-interval curve (S-I curve), which was made by plotting the shortest intervals required to evoke the excitation for various intensities.
- 社団法人日本循環器学会の論文
- 1968-05-20
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