On the Noradrenaline Reaction of the Adrenal Medulla in Experimental Hypertensive Rats, Especially in Spontaneously Hypertensive Rats : II. Effects of Various Experimental Conditions on the Noradrenaline Storing Cell Islets of the Adrenal Medulla in Spont
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The reaction of noradrenaline in the adrenal medulla was observed by COUPLAND et al.'s method under various experimental conditions such as rotating exercise, anesthesia, operation, disease and by using 175 spontaneously hypertensive rats and control rats and the following results were obtained. (1) Rotating exercise decreased the area of the noradrenaline storing cell islets both in spontaneously hypertensive rats and in control rats. Spontaneously hypertensive rats showed a higher rate of decrease and greater grade of decrease than control rats. As for the grade of decrease during the various duration of exercise, it was the highest within the first 30 seconds of exercise and after that, even though the duration of exercise was longer, only a slight decrease was observed. (2) When the rats rested after 1 minute of rotating exercise, the area of the noradrenaline storing cell islets in the adrenal medulla was restored gradually and after 1 hour of rest, the area of the noradrenaline storing cell islets of the adrenal medulla in spontaneously hypertensive rats was restored to the same state found before the exercise was loaded, but control rats showed only, 82 per cent restoration. (3) The area of the noradrenaline storing cell islets both in, spontaneously hypertensive rats and in control, rats remarkably decreased under Nembutal anesthesia and the grade of decrease in the former was greater but there was no difference in the rate of decrease between spontaneously hypertensive rats and control rats. (4) The area of the noradrenaline storing cell islets after the resuscitation from Nembutal anesthesia tended to decrease until the 12th hour after Nembutal injection and tended to increase after that, and 24 hours after Nembutal injection, the area of spontaneously hypertensive rats was restored to 77.5 per cent of that under the minimum stress and that of control rats was restored to 80.6 per cent. However, the actual grade of restoration was greater in the former than in the latter. (5) A decrease in the area of the noradrenaline storing cell islets at the time of operation under Nembutal anesthesia was more remarkable than simply under Nembutal anesthesia without operation. The grade of decrease and the rate of decrease in the area of noradrenaline storing cell islets in spontaneously hypertensive rats were greater than those of control rats. (6) The area of the noradrenaline storing cell islets of the adrenal medulla in spontaneously hypertensive rats decreased from 60 per cent to 0 per cent of the area under the minimum stress when they suffered from severe pneumonia. (7) As time elapsed after death, the intensity of the staining of the noradrenaline storing cell islets both in spontaneously hypertensive rats and in control rats decreased and the speed of the decrease in spontaneously hypertensive rats was quicker than that of control rats by 2 to 4 hours. The area of noradrenaline storing cell islets in spontaneously hypertensive rats and in control rats decreased gradually as time elapsed after death, and the rate of the decrease in the area was greater in spontaneously hypertensive rats than in control rats (8) From the above-mentioned results, it can be suggested that both synthesis and secretion of the noradrenaline of the adrenal medulla in spontaneously hypertensive rats are increased as compared with those of control rats.
- 社団法人日本循環器学会の論文
- 1968-03-20
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関連論文
- Enzyme Histochemical Studies on the Hypothalamus of Spontaneously Hypertensive Rates : With Special Reference to That of Rats Subjected to Various Endocrinc Interferences
- On the Noradrenaline Reaction of the Adrenal Medulla in Experimental Hypertensive Rats, Especially in Spontaneously Hypertensive Rats : I. Histochemical and Histometrical Studies on the Noradrenaline Storing Cell Islets of the Adrenal Medulla in Various E
- On the Noradrenaline Reaction of the Adrenal Medulla in Experimental Hypertensive Rats, Especially in Spontaneously Hypertensive Rats : II. Effects of Various Experimental Conditions on the Noradrenaline Storing Cell Islets of the Adrenal Medulla in Spont