Hepatic Circulation in Hemorrhagic and Anaphylactic Shock : ITS BEARING ON SYSTEMIC CIRCULATION

スポンサーリンク

概要

• 論文の詳細を見る

• 1) Hepatic circulation in hemorrhagic and anaphylactic shock was studied upon dog experiments, with special emphasis on its relation to systemic circulation. 2) The results on hemorrhagic shock are diagrammatically summarized in Fig. 1 2. During the stage of "simple hypotension ", concomitant changes were observed in the main features of hepatic and systemic circulation, as indicated in the Figure. However, during sub-sequent irreversible phase, the changes in hepatic circulation were no more in parallel with systemic hemodynamic alterations. In particular, the more pronounced diminution was revealed in hepatic blood flow than in cardiac out-put with a resultant " gap" between those two variables. This gap seems to be the most characteristic feature of this critical state of shock, and may result from increased splanchnic vascular resistance. Other problems such as the significance of the blood pooling in the splanchnic bed were discussed in connection with the foregoing events. 3) During anaphylactic shock, the features of hepatic circulation varied in parallel with systemic hemodynamic alterations, except at a brief period just after the provocation to shock. At this cirtical period, hepatic blood flow was reduced pronouncedly with the accompanying but less pronounced diminution in cardiac out-put, and, there was a sharp rise in portal vein pressure, a marked increase in splanchnic vas-cular resistance and a simultaneous fall in inferior vena caval pressure. All of these phenomena may be ascribed to " hepatic sluice mechanism" due to the constriction of the hepatic venous sphincters. Marked congestion and plasma extravasation was observed in the liver. 4) Splanchnic oxygen utilization became significantly impaired, in both types of shock, despite the increased arterio-venous oxygen difference. 5) Catecholamine concentration in arterial blood rised continuously throughout the course of hemorrhagic shock, but it rised temporarily in anaphylactic shock just after the provocating injection. The possible role of the fact was discussed in connection with its action on splanchnic vascular resistance. The details of the present investigation will be submitted by our collaborators as separate publications.

• 社団法人日本循環器学会の論文
• 1964-02-20

著者

• Tanabe Yoshinori

  The 2nd Division Department Of Internal Medicine Hokkaido University School Of Medicine

• Kinoshita Shinji

  The 2nd Division Department Of Internal Medicine Hokkaido University School Of Medicine

関連論文

• Hepatic Circulation in Hemorrhagic and Anaphylactic Shock : ITS BEARING ON SYSTEMIC CIRCULATION
• Effect of Tobacco Smoking on the Heart Especially in Young Adults

スポンサーリンク