Changes in Blood Pressure and Ionic Shift

概要

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The role of catecholamines in the accumulation of sodium and water in the vascular walls of hypertensive patients was examined. The excess production of catecholamines was not found in hypertensive patients. During the rise of blood pressure induced by norepinephrine, the concentration of plasma sodium decreased and that of plasma potassium increased. No significant difference could be found between hypertensive patients and normal subjects in these cationic shifts. Water also moved into intracellular space during the rise of blood pressure. The influx of ^<22>Na in the aorta strips of rats was found to be potentiated by norepinephrine, while that of ^<86>Rb seemed to be hindered. The influx of ^<22>Na in the aorta strips in the group of hypertensive rats was significantly greater than that seen in the group of normotensive rats. The relationship of these cationic shifts to the pathogeneses of "essential" hypertension has been discussed.
社団法人日本循環器学会の論文
1964-02-20