EFFECTS OF d-α-TOCOPHERYL NICOTINATE ON CORONARY CIRCULATION AND DEVELOPMENT OF CORONARY COLLATERAL VESSELS

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概要

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• The influence of dl-α-tocopheryl nicotinate on coronary arterial circulation, particularly the development of collateral vessels in the heart of 48 Beagle dogs was investigated. The drug (100 mg/kg) was given orally before and after ligation of the anterior descending branch of the coronary artery. The experimental animals were separated into 5 groups according to the mode of drug administration, i.e. normal control, ligated control, and 3 medicated groups. the total period of the experiment was 5 months for each groups. We examined the general conditions, the electrocardiogram, the treadmill loaded electrocardiogram, and "back pressure" and "back flow" at the area of the ligated coronary artery immediately before sacrifice, and anastomoses by coronary arterial roentgenography and histological examination after sacrifice. The following results were obtained; 1) There was no difference in the number of coronary arterial anastomoses between the ligated control group and the EN medicated groups. However, the small arteries of the "large or very large" class with a diameter of 401μ or more were increased to a greater extent in the EN medicated groups when the drug was given after ligation, or before and after ligation. 2) "Back flow"/systemic pressure showed a significant increase in the EN medicated groups after ligation, or medicated before and after ligation as compared with the ligated control group (P < 0.01 and P < 0.05 respectively). 3) An increase in "back pressure"/systemic pressure was found in the EN medicated groups after ligation and those medicated before and after ligation, but such was not statistically significant. 4) The increase in heart rates with the treadmill test was less in the EN medicated groups than in the ligated control group. It would appear that dl-α-tocopheryl nicotinate accelerates the formation of the large collateral vessels and increases the reserve capacity in ventricular function in experimentally induced myocardial infarction in dogs.

• 社団法人日本循環器学会の論文
• 1977-11-20

著者

• Yasue Takao

  2nd Dept of Int Med, Gifu Univ

• Yasue Takao

  2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• OJIMA Akitsugu

  2nd Department of Pathology, Gifu University School of Medicine

• HAYASE SHOJI

  2nd Department of Internal Medicine, Gifu University School of Medicine

• Ojima Akitsugu

  2nd Department O Fpathology. Gifu University School Of Medicine

• Kato Toshihiko

  2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Hayase Shoji

  2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Hayase Shoji

  2nd Department Of Internal Medicine Gifu University School Of Medicine

• TESHIGAWARA SEIJI

  2nd Department of lnternal Medicine, Gifu University School of Medicine

• KOBAYASHI HIROSHI

  2nd Department of lnternal Medicine, Gifu University School of Medicine

• SHOJI YOSHITAMI

  2nd Department of lnternal Medicine, Gifu University School of Medicine

• SUGIYAMA KAZUTAKE

  2nd Department o fPathology. Gifu University School of Medicine

• SAGAMI FUMIO

  EISAI Co. Biological Institute

• Shoji Yoshitami

  2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Teshigawara Seiji

  2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Kobayashi Hiroshi

  2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Kato Toshihiko

  2nd Department of lnternal Medicine, Gifu University School of Medicine

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