Studies on the Ftiology of Essential Hypertension : a Role of Sympathetic Nervous System

概要

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1) A role of aldosterone in the etiology of essential hypertension is yet obscure ; except severe and malignant hypertension which have an increased renal damage. However in the latter two diseases aldosterone has some significance in the maintenance of hypertension. 2) We have found the cases with primary aldosteronism showed a normokalemic stage especially in their initial stadium. 3) In our experienced cases of primary aldosteronism there were some cases of so-called secondary primary aldosteronism with bilateral adrenocortical hyperplasia (zona glomnerulosa). 4) In diagnoses of primary aldosteronism only the suppression of P.R.A. response is not satisfied and the existence of hyperaldosteronism must be recognized, because not a little percentage out of essential hypertension show often a low P.R.A. and P.R.A. response to sodium restriction and upright position. More sensitive and accurate method of determining plasma renin is necessary to resolve the problem which include a true incidence of primary aldosteronism in essential hypertension. 5) From our cases histologically the following possibility was considered that first zona glomerulosa caused hyperplasia and thereafter gradually transit to adenomatous hyperplasia and matured adenoma.
社団法人日本循環器学会の論文
1971-06-20