Interaction of Angiotensin and Noradrenaline in Rat's Hindlimb Preparation. : A Possible Mechanism of the Experimental Renal Hypertension
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概要
- 論文の詳細を見る
Interaction of angiotensin and noradrenaline on vascular responsiveness were investigated in the isolated rat's hindlimb preparations perfused with Tyrode solution in low perfusion pressure. Highly significant enhancement of responses to noradrenaline occurred in angiotensin infusion with concentration influenced or uninfluenced to the perfusion pressure. Diminished responses of repeated application of angiotensin, tachyphylaxis, easily produced in the preparation, were promptly reversed by an application of noradrenaline and no tachyphylaxis was made as far as both sub-stances were alternately administered. In the possible mechanism of the experimental renal hypertension, the participation of interaction in renin-angiotensin and sympathetic neurohumoral agent on the peripheral sites of the circulating system were suggested.
- 社団法人日本循環器学会の論文
- 1971-06-20
著者
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Sato Rihei
The Ist Dept. Inter. Med. Univ. Of Tokyo
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Masuyama Yoshiaki
The Ist Dept. Inter. Med. Univ. Of Tokyo