ジギタリス感受性に関する血行力学的研究,特に色素稀釈法による検討

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概要

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• Although a variety of factors, both exogeneous and endogeneous, has been known to alter the toxic action of digitalis, literatures dealing with the hemodynamic studies on the sensitivity to digitalis are scanty. Present study on the sensitivity of dogs to digitalis from hemodynamic aspects revealed the significant relationship between sensitivity to digitalis and hemodynamics. Furthermore, a close correlation was found between cardiac output and appearance time of dye dilution curve. Materials and Methods Healthy adult dogs were anesthetized by intraperitoneal administration of sodium pentobarbital (35-50 mg/kg). After intubation with endotracheal tube, room air mixed with 100 per cent oxygen was given by respirator. Dye dilution curve was recorded at time intervals after injection of indocyanine green (2-3 mg) into the vena cava near the right atrium and by sampling from the femoral artery. Aortic pressure was measured by the catheter placed in abdominal aorta. Electrocardiogram was monitored and recorded. (1) The determination of cardiac output by the triangle method. In order to determine the cardiac output, Cambridge dye dilution curve recorder was used. The author's modified triangle method was per-formed for the determination of the area of dye dilution curve by the following equation: fcdt = ΔXYZ + 1/10 ΔXYZ since Cambridge dye dilution curve recorder did not show lineality between dye concentration and absorbance in this experiment. (2) Hernodynamic studies on the sensitivity of dogs to digitalis. Nineteen healthy adult dogs weighing 8-16 kg were used. Before administration of strospeside, electrocardiogram, aortic pressure and dye dilution curve were recorded. Thirty minutes after intravenous administration of 0.3 mg/kg of strospeside, the dogs were divided into two groups electrocardiographically; The first group included dogs in which ventricular tachycardia continued more than thirty minutes or ventricular arrest occurred, the second group included dogs in which ventricular tachycardia did not occur or appeared transiently. Then the differences of hemodynamic and electrocardiographic findings before administration of strospeside between two groups were surveyed.

• 社団法人日本循環器学会の論文
• 1970-01-20

著者

• 渡会 昌広

  名大第3内科

• 渡会 昌広

  名古屋大学医学部内科学第三講座

関連論文

• ピルビン酸ソーダ投与時の血行動態(第1報) : 第28回東海・第5回北陸合同日本循環器学会地方会
• 心内心音法の臨床的応用(第3報)心室中隔欠損症について(PartI) : 日本循環器学会第26回東海第2回北陸合同地方会総会
• ジギタリス中毒の実験的研究 : 第VI報 : 特に色素稀釈法による検討 : 日本循環器学会第25回東海・第1回北陸合同地方会総会
• ピルビン酸ソーダ投与時の血行動態に関する実験的研究(第2報)
• 色素稀釈法の理論的解析と臨床応用について : 循環器疾患の新しい診断技術 : シンポジウムII : 第28回東海・第5回北陸合同日本循環器学会地方会
• ジギタリス感受性に関する血行力学的研究,特に色素稀釈法による検討
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