動脈硬化症の成因に関する研究 : 大動〓壁への血清リポ蛋白清取リ込みについて

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Doubtlessly there are a number of factors participating in the pathogenesis of arterio-sclerosis, and it has been immunologically and dietetically established through experiments on animals that lipemia and a chronological factor, above all, are playing important roles. As the origin of the lipid deposited on the sclerotic lesion opinions are diversified ; some attributing it to blood, others to the synthesis in the arterial wall and so forth, but at present the former seems to have gained general acceptance. Any lipid in a living body exists in the form of lipoprotein, therefore, if the lipid in the sclerotic lesion is to have been derived from blood, the process may have been accomplished through lipoprotein. There have been so far a few reports concerning the influx of lipid into the aortic endothelium studied with radioactive cholesterol as a tracer. In the present investigation, the influx of lipid in the form of lipoprotein was studied both in vitro and in vivo, and the following results were obtained : (Table I) Results A) In vitro 1) Determination of radioactivity of the various component of lipids in serum low and high density lipoproteins were made three hours after the administration of cholesterol-4-C^<14> to the rabbit. Both with low and high density lipoproteins, most of the radioactivity was seen concentrated on free cholesterol. 2) Using the above mentioned low and high density lipoproteins, the aortic wall of the rabbit was incubated for three hours within the Warburg aparatus confiming the survival of the tissue. As a result, it was found that the influx in the normal aortic endothelium was higher than that in the plaque area. The value was also higher for the normal aortic endothelium plus mesothelium than that for the plaques. It appeared that radioactivity was reduced in the aortic wall denatured by 30 minutes boiling, compared with that the living one.
社団法人日本循環器学会の論文
1968-09-20

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