Bioassay of ADH on the Experimental Diabetes Insipidus Rats with a Study on the ADH Level in Normal Human Plasma

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概要

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• The rats whose median eminence of the hypothalamus was destroyed were used for bioassay of ADH with modified DISCKER'S method. The constant hydration was maintained by the intravenous route and changes in urinary volume were used as the index of response. It was shown that the experimental diabetes insipidus rats were about four times more sensitive to ADH than the normal rats. The smallest dose which could be detected in the present study was 2.5μu per rat. ADH level in normal human plasma was less than 2.1μu/ml after dehydration of 13 to 16 hours.

• 社団法人日本循環器学会の論文
• 1966-12-20

著者

• Yamane Yoko

  The Third Division Department Of Internal Medicine. Faculty Of Midicine Kyoto University

• Kunishige Kazuhiko

  The Third Division Department Of Internal Medicine. Faculty Of Midicine Kyoto University

• YAMANE Y.

  The Tasaka Clinic, Tokyo University, Medical School

関連論文

• 25) Studies on the Correlationship between the Myocardial Oxygen Tension and Electrocardiographic Changes during Coronary Occlusion and Narrowing(Proceedings of the 24th Annual Meeting, The Japanese Circulation Society [Part I])
• Bioassay of ADH on the Experimental Diabetes Insipidus Rats with a Study on the ADH Level in Normal Human Plasma

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