慢性腎不全に対する低蛋白食餌とインシュリンの併用療法に関する臨床的研究

スポンサーリンク

概要

• 論文の詳細を見る

• Twenty patients, 14 males and 6 females, 18 with chronic renal failure, 14 from chronic glomerulonephrities and 4 from nephrosclerosis, and 2 with chronic glomerulonephrities, were treated with low protein diet and regular insulin administration. The low protein diet used contained essential amino acids in quantities larger than the minimum requirement of amino acids as reported by the Food and Agriculture Organization Committee (F.A.O.). 1) In patients with a GFR of 20.1 to 30.0 % of normal, serum non-protein nitrogen and serum urea nitrogen decreased to normal and maintained a normal level under low protein diets of 0.4 to 0.6 g/day/kg body weight. 2) Patients with chronic renal failure with a GFR of under 30% of normal value revealed azotemia under protein intake of more than 0.8 g/day/kg body weight. 3) Five patients with chronic renal failure revealed increased or unchanged serum non-protein nitrogen and serum urea nitrogen, and an increased serum amino acids solution (3% ES. Politamin R), but unchanged or in some cases decreased serum non-protein nitrogen and serum urea nitrogen, and decreased serum amino nitrogen in all cases when 10 units of regular insulin was added to the amino acids solution. 4) Three out of four patients with chronic renal failure revealed decreased serum non-protein nitrogen, serum urea nitrogen and serum potassium level with a decreased urinary total nitrogen and urea nitrogen output after daily intravenous infusion of 500ml of 5% glucose solution with 10 units of regular insulin over a 5 hour period for 20 days. 5) Patients under low protein diets of 0.4 to 0.6g/day/kg body weight revealed decreased serum non-protein nitrogen and serum urea nitrogen level, and decreased urinary total nitrogen and urea nitrogen output, in almost all cases after daily intramuscular administration of 10 units of regular insulin for 20 days. Hyperpotassemic patients revealed decrease in serum potassium level.

• 社団法人日本循環器学会の論文
• 1965-10-20

著者

• 吉田 弘

  京都大学医学部内科第三講座

関連論文

• 68)腎臓の機能と構造に関する研究(第V報) : Latent Nephritisにおける臨床像と生検像 : 講演会一般演題
• 腎臓の機能と構造(第3報) : 絲球体腎炎患者の臨床像と生検像 : 第26回日本循環器学会総会
• 腎臓の機能と構造 (第2報) : 老年者および本態性高血圧症患者の臨床像と腎生検像 : 第25回日本循環器学会総会
• 慢性鬱血性心不全時の "Water-Electrolyte Regulation Mechanism" の臨床的研究 : 二, 三の利尿剤の臨床的検討 : 第25回日本循環器学会総会
• 慢性腎不全に対する手術的療法 : 第28回関西地方会
• 心房細動に対するレセルピン ・ キニジン併用療法について (第2報) : 第25回日本循環器学会総会
• 慢性腎不全に対する低蛋白食餌とインシュリンの併用療法に関する臨床的研究
• 抗凝固剤による Fallot 四徴候の非観血療法の試み(予報) : 第26回日本循環器学会総会

スポンサーリンク