SEQUENCE IN DNA SYNTHETIC PHASE RATIO OF SPONTANEOUS HYPERTENSIVE RAT (SHR) MYOCARDIUM : Study on Development of Cardiomegaly
スポンサーリンク
概要
- 論文の詳細を見る
We studied the relative synthetic phase (S-phase) ratio of cardiac myocytes of spontaneously hypertensive rats (SHR) utilizing monoclonal antibody to 5-bro-mo 2'-deoxyuridine (BrdU), a halogen derivative of thymidine. BrdU was administered intraperitoneally to SHR and Wistar Kyoto rats at 66.7 mg/kg/day for 3 consecutive days. The rats were sacrificed I week after the first injection of BrdU. Using anti-BrdU antibody, myocardial tissue was stained by the avidin biotinylated peroxidase complex method. We assessed the ability of the nuclei to synthesize DNA. The percentage of BrdU-labeled myocyies was higher in SHR than in control rats at 9 weeks. The hyperplastic phase of heart growth in rats was presumed to occur about 3 weeks after birth. From these results, the ability of the myocardial cell to synthesize DNA is probably enhanced under the load of high blood pressure in the early hypertrophic phase following hyperplasia.
- 社団法人日本循環器学会の論文
- 1993-05-20
著者
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Tachibana Hideaki
Third Department Of Internal Medicine Showa University School Of Medicine
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Inoue Shin
Internal Medicine Showa University School Of Dentistry
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Ando Harunori
Third Department of Internal Medicine, Showa University
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Inoue Shin
The Third Department of Internal Medicine, Showa University School of Medicine
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Tachibana Hideaki
The Third Department of Internal Medicine, Showa University School of Medicine
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Oki Hiroyoshi
Third Department Of Internal Medicine Showa University
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Ando Harunori
Third Department Of Internal Medicine Showa University
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Katagiri Takashi
The Third Department Of Internal Medicine Showa University
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OKI HIROYOSHI
The Second Department of Pathology, Showa University School of Medicine
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ANDOU HARUNORI
The Second Department of Pathology, Showa University School of Medicine
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