Hypertension Induced by Extensive Medial Anteromedian Hypothalamic Destruction in the Rat

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概要

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• 1. Extensive lesions in medial anteromedian hypothalamus induced severe to moderate hypertension in Wistar rats. 2. Sites of lesions indispensable to the production of hypertension proved to be anterior hypothalamic area, ventromedial nucleus, anteromedian part of arcuate nucleus and periventricular nucleus located medial to these nuclei, while the lesions involving pituitary stalk, posterior portion of arcuate nucleus and large portions of mammillary region prevented the development. 3. This hypertension was potentiated by, or in some instances, dependent on salt loading. 4. In the hypertensive animals, remark-able adrenal hypertrophy was present in association with increased plasma corticosterone. Increase in plasma corticosterone was also detected in the hypothalamus-lesioned animals in the early hypertensive stage. 5. Adrenal glomerular zone was atrophied in many rats, subjected to medial anteromedian hypothalamic destructions. 6. Renal lesions, such as thickened capsules and basement membranes of proximal convolutions, often resulting in tubular deteriorations and cystic dilations, were observed in the animals with medial anteromedian hypothalamic lesions, regardless of whether they were hypertensive or not. 7. Vascular lesions detected in the rats which developed hypertension following hypothalamic lesions, were periarteritis nodosa, arteriolar necrosis, productive arteriolitis with or without fibrinoid necrosis and glomerular necrosis. 8. It is concluded that the augmented adrenocortical secretion, probably in conse-quence of eliminated corticoids feed-back mechanism due to hypothalamic lesions, plays the major role in the pathogenesis of this hypertension.

• 社団法人日本循環器学会の論文
• 1966-05-20

著者

• Nosaka Shoichiro

  The Department Of Pathology Faculty Of Medicine Kyoto University

• Nosaka Shoichiro

  The Department Of Pathology Faculiy Of Medicine Kyoto University

• Nosaka S.

  The Department of Pathology, Faculty of Medicine, Kyoto University

関連論文

• Enzyme-histochemical Studies on the Brain Stem of Spontaneously Hypertensive Rats
• Further Observations of the Development of a Strain of Spontaneously Hypertensive Rats
• Experimental Hypertension and Hypotension Induced by Hypothalamic Destruction in the Rat
• Cardiovascular Diseases in the Spontaneously Hypertensive Rat
• Hypertension Induced by Extensive Medial Anteromedian Hypothalamic Destruction in the Rat

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