Factors Influencing Vascular and Natriuretic Responses to ANP : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society

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概要

• 論文の詳細を見る

• To explore factors that modulate the magnitude of vasorelaxation and natriuretic/diuretic responses to exogenous ANP, clearance studies were performed in unilateral hydronephrotic rats with renal vasocontraction complications. An increase in renal plasma flow associated with a decrease in calculated renal vascular resistance in response to ANP (2 μg・min^<-1>・kg^<-1>, i.v.) was obtained only in the hydronephrotic kidney. In contrast, the control kidney of the unilateral hydronephrotic rat had a decrease in glomerular filtration rate and an abolished natriuretic response following ANP administration. A prior renal denervation in the control kidney restored the natriuretic effect of ANP and obolished the lowering of glomerular filtration rate. These data suggest that the vasodilatory effect of ANP may depend on the vascular tone itself, and that renal responses to ANP are significantly modified by renal nerve activity.

• 社団法人日本循環器学会の論文
• 1988-12-20

著者

• Torikai Shozo

  Department Of Pharmacology National Cardiovascular Center Research Institute

関連論文

• Factors Influencing Vascular and Natriuretic Responses to ANP : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society

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