Effects of Some Antianginal Agents on Nonepinephine Turnover in Heart -With Special References to Role of Adrenocortical Function, Sympathetic and Parasympathetic Tone Regulation Norepinephrine Turnover

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NEp content and turnover rate following α-MPT were examined in rat heart after the use of several drugs. 1) Turnover rate were decreased by all of three anti-anginal agents, but, remarkbly by nitrate and propranolol, while slightly by prenylamine which lowered NEp content in the heart. Through these observations it seemed that the suppression of adrenergic activity might be one of the pharmacological mechanism of anti-anginal agents. 2) Atropine, hexamethonium and hydrocortisone showed no effect on NEp level in heart, but dexamethasone lowered NEp con-tent. Turnover rate were suppressed by dexamethasone, accelerated by atropine, but not changed by hydrocortisone and hexamethonium. It is suggested that not only the sympathetic system, but also the adrenocortical function, especially glucocorticoid fraction, are one of the factors regulating NEp synthesis. Since the adrenergic mechanism is very complicated, further study in being made to elucidate these problems.
社団法人日本循環器学会の論文