反脈動法(Counterpulsation)の死後冠動脈造影像に及ぼす効果に関する実験的研究

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Various types of assisted circulation have been clearly classified according to indication through the serial experimental and clinical investigations by Akune and the co-workers. Counterpulsation (CP), a method of assisted circulation for left-sided heart failure, principally provides assist to the left ventricle and augmentation of the coronary circulation owing to a phase shift of the pressure curve produced in the aortic root. In spite of no difference of opinion concerning the assisting effect of CP on the left ventricle, controversy continued as to whether CP can augment coronary blood flow. Thus, the author has attempted to clarify morphologically the effect of CP using a new counterpulsator SIMAS on the canine coronary circulation by means of postmortem coronary angiography. The experiments were done on 20 adult mongrel dogs, which were divided into the 2 groups : the control group (CT group) of 10 dogs and the counterpulsation group (CP group) of 10 dogs. All the experimental conditions including cannulation except the performance of CP were maintained identical in the both groups. Both in CT and CP groups, an arterial cannula was inserted via the bifurcation of the abdominal aorta, its tip being placed in the mid-portion of the thoracic descending aorta. CP was performed for 1 hour under proper synchronization with the cardiac cycle on condition that aortic mean pressure was slightly elevated, in CP group. Such parameters as ECG, aortic pressure, central venous pressure were measured and recorded throughout the experiment. Immediately after CP discontinued in CP group or after 1 hour following cannulation in CT group, the heart was removed and postmortem angiography was carried out.
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反脈動法(Counterpulsation)の死後冠動脈造影像に及ぼす効果に関する実験的研究

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