老年者腎循環に対する低酸素気呼吸の影響に関する臨床病態生理学的研究(前編)
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Many papers on the renal functional of old age have already been published. Much of these, however, are concerned only with the resting state. The author attempted to examine the reactivity of renal circulation against stresses produced by inhalation of low oxygen gas of old age subjects whose urine was negative of albumin. Method s Renal circulation values were determined by the standard renal clearance method during the inhalation of room air and successive inhalation of mixed gas consisting of 10% O_2 and 90% N_2. The saturation of arterial oxygen (SaO_2) range-d from 46 to 77 per cent (average: 61 per cent). Materials Older men (34 persons) and women (10 persons), a total of 44 persons in an alms-house, who had no particular disease and whose urine were negative of albumin were studied. Ages ranged from 51 to 83, and their blood pressure from 100 to 210mmHg, systolic, and from 60 to 160mmHg diastolic. PSP tests were also performed and the 15-minute values ranged from 51 to 42 per cent. Among these examined, 23 persons (16 men and 7 women) were subjected to the hypoxic loading test and their renal hemodynamics were compared before and after the inhalation of low oxygen gas. The subjects were classified as follows : 1) Classified by age : Group I (Under 69 years old) 23 persons examined under room air inhalation and 14 of these also under the low oxygen gas. Group II (Over 70 years old) 21 persons examined under room air inhalation and 9 of these also under the low oxygen gas. 2) Classified by arterial blood pressure: Group A-Systolic blood pressures lower than 149mmHg accompanied with diastolic pressures less than 89mmHg (senile normotension type). Seventeen persons room air inhalation and 10 persons under 10% O_2. Group B Systolic blood pressures over 1) Age: 150mmHg, accompanied with the diastolic pressures of less than 89mmHg (senile hypertension type). Twelve persons under room air and 5 under 10% O_2. examinations, the seventies gave distinctly Group C Systolic blood pressures over 150mmHg, accompanied with diastolic pressures of more than 90mmHg (essential hypertension type). Fifteen persons under room air and 8 under 100% O_2.
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