Histologic Features of Renal Biopsies from Patients with Essential Hypertension and from The Aged

概要

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In order to clarify the vascular changes involved in the kidneys in essential hypertension, a histological study was performed on the renal biopsy materials obtained from 15 patients with juvenile form of essential hypertension, 30 elderly patients with essential hypertension, and 10 ordinary aged persons without hypertension, who admitted in the third medical clinic of Kyoto University Hospital between 1959 and 1963. It was found that the renal vascular disease in essential hypertension was predominantly in the small arteries and arterioles, especially in the media of arterioles, and included spasm, hypertrophy with or without vacuolation, hyperplasia, degeneration, atrophy with fibrosis and fibrinoid degeneration or necrosis of the medial smooth muscle. Intimal proliferation appeared to follow the changes in the media, while in the ordinary aged persons intimal sclerosis occurred from larger arteries with milder degree of severity. These flndings suggest that fundamental importance in the development of systemic hypertension should be attached to the problems on the contraction of the smooth muscle cells of the peripheral small arteries and arterioles.
社団法人日本循環器学会の論文