冠動脈導管法による実験的冠循環の研究 : 諸種薬剤の冠循環に対する直接効果並びにその心電図に就いて : 第四篇 Theophylline ethylenediamineの冠循環に対する直接効果と心電図

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• The author attempted to examine the action of theophylline ethylenediamine, so-called coronary dilator, by following the effect of the direct infusion of the drug into the left coronary artery through a coronary artery catheter in anesthetized, closed-chest dogs. Electrocardiographic changes caused by the infusion of the drug were also studied.Method : In addition to the experimental method described in part I, the left coronary artery was also perfused from a donor dog's femoral artery at a constant blood pressure. The experiments were done 6 times on 2 adult dogs. Leads C_<ψD> and C_<ψS>, representing right and left ventricular electrocardiogram, respectively, were used in taking serial electrocardiograms.Results : (1) Experiments with coronary artery perfusion from the dog's own femoral artery(a) With 12.5 mg of theophyline ethylenediamine coronary blood flow flincreased, while coronary wedge pressure and femoral arterial pressure showed no change.(b) With 25 mg of theophylline ethylenediamine coronary blood flow decreased, coronary wedge pressure showed no change, and femoral arterial pressure fell.(c) With 125mg of theophylline ethylenediamine coronary blood flow decreased, coronary wedge pressure fell and femoral arterial pressure became markedly reduced.(2) Experiments with coronary artery perfusion from a donor dog's femoral artery under constant blood pressure(a) Infusion of 12.5 mg of theophylline ethylenediamine caused a slight decrease in coronary blood flow, an elevation in coronary wedge pressure and no change in femoral arterial pressure.(b) With 25 mg of theophylline ethylenediamine coronary blood flow increased, while coronary wedge pressure and femoral arterial pressure fell.(c) Infusion of 62.5 mg of theophylline ethylenediamine caused an increase in coronary blood flow, a fall in coronary wedge pressure and a marked fall in femoral arterial pressure.Conclusions : (1) Theophylline ethylenediamine tends to exert a vaso-dilating action on the coronary vessels.(2) Infusion of a large amount of theophylline ethylenediamine caused a dangerous decrease incoronary blood flow followed by a fall in aortic pressure.(3) The electrocardiogram showed a tendency to elevation of the S-T segments with a slight increase in the heart rate.

• 社団法人日本循環器学会の論文
• 1960-07-20

著者

• 桝田 喜久吾

  京都大学医学部内科学第三講座

関連論文

• 冠動脈導管法による実験的冠循環の研究 : 諸種薬剤の冠循環に対する直接効果並びにその心電図に就いて : 第五篇 Nicotine並びにEthyl alcoholの冠循環に対する直接効果とその心電図
• 冠動脈導管法による実験的冠循環の研究 : 諸種薬剤の冠循環に対する直接効果並びにその心電図に就いて : 第四篇 Theophylline ethylenediamineの冠循環に対する直接効果と心電図
• 冠動脈導管法による実験的冠循環の研究 : 諸種薬剤の冠循環に対する直接放果並びにその心電図に就いて 第三篇 Noradrenalineの冠循環に対する直接効果と心電図
• 冠動脈導管法による実験的冠循環の研究 : 諸種薬剤の冠循環に対する直接効果並びにその心電図に就いて : (第一篇)総論及び対照実験

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