灌流蟇心に於けるStarling曲線と活動発電量との関係についての実験的研究
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概要
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According to the Maekawa's theory of the electrocardiogram (1944) the integrated monophasic action potential of the heart muscle is to be proportional to its mechanical work. The aim of this study is to investigate this theory in the excised perfusate toad heart in the Starling's law of the heart.Method : For realizing the Starling's law in exercised toad heart a venous reservoir and a peripheral resistance were connected to its inflow side and outflow side respectively. In this experiment only the inflow load was changed and the outflow load was fixed at 25 mm. of water above the inflow level. And the tachography was made by the specially designed recording system in order to show the relation between the inflow and the outflow. The integrated monophasic action potential was obtained by means of the electriacl integrator circuit and the modified Wigger's suction electrode.Results : The Starling's law of the heart holds in the perfusated toad heart at the inflow pressure ranging from slightly above 0 mm. to 30 mm. of water. And the amplitude of the integrated monophasic action potential (E) were proportionally increased with the output at the inflow pressure ranging from slightly above 0 mm. to 10 mm. of water, but decreased at the inflow pressure above this in spite of the increase of the output. This is becase the heart is sufficiency dilated to realize the law of 1/R^2 where R is the radius of the heart cavity assumed as a cube. So the radii were calculated from experimental data and ER^2 obtained. Then the values show the direct proportion to the output as in the case of the Starling's law of the heart.From these results, confined the Maekawa's theory of the heart contraction which denotes I=αM. I=∫E・dt E : action potential in monophasic Form M : mechanical work.
- 社団法人日本循環器学会の論文
- 1960-01-20