体位連続変換による肺動脈圧の変動に関する研究 : 主として調和分析による研究 : 〔附〕交感神経β受容体遮断剤投与実験

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Both the wave of changing body position per-formed by means of the change table devised by us and the wave of pulmonary arterial pressure in horizontal position or during changing body position were simulaneously recorded on a magnetic tape by using Sony's data recorder, in each of 25 patients with pulmonary tuberculosis. The position of the change table was altered continuously like a sine curve to the extent of ±15 degrees. The pulmonary arterial pressure was picked up by an intracardiac microtransducer. The recorded magnetic tape was reproduced on an endless tape of Sony's analogue magnetic correlator. Then, each autocorrelogram of the wave of pulmonary arterial pressure and of the wave of changing position, and a crosscorrelogram between the both waves were calculated by setting the correlator with the tape. The systolic, diastolic and pulse pressures were measured respectively on the pulmonary arterial pressure recorded in horizontal position and during changing position. In the same way, the period and the decrease grade of wave amplitudes were measured respectively on the autocorrelogram of pulmonary arterial pressure recorded either in horizontal position or during changing position, and on the crosscorrelogram between the wave of pulmonary arterial pressure recorded during changing position and that of changing the table. The power density spectrum of pulmonary arterial pressure was calculated by a digital computer. The relations between these results and the amount of urinary catecholamine as well as cardiac output were investigated in the patients. Propranolol, a kind of beta-adrenergic blockade, was injected into pulmonary artery to investigate its influence on the alteration of pulmonary arterial pressure caused by continous change of body position, too. The following results were obtained: At the position of +15 degrees in course of changing position like a sine curve, the pulmonary arterial systolic and diastolic pressures were lower, pulse pressure seemed to be lower compared with those at the horizontal position. At the position of -15 degrees in course of changing position in the same way, the pulmonary arterial systolic and diastolic pressures seemed to be higher, and the pulse pressure was the same, compared with those at the hirizontal position. The decrease grade of amplitude of the autocorrelogram of pulmonary arterial pressure recorded during changing position was smaller than that recorded at the horizontal position. Power density spectrum of pulmonary arterial pressure began to decrease distinctly from 4 cps and then converged on zero. The alteration of wave amplitude and the displacement of wave phase were found between the power density spectrum curve of pulmonary arterial pressure at the horizontal position and that during changing position. No significant correlation was found between the alteration of pulmonary arterial pressure caused by changing position and the amount of urinary catecholamine as well as the cardiac output. The alteration of pulmonary arterila pressure resulting from changing position continuosly tended to disappear after the injection of propranolol. The alteration of wave amplitude and the displacement of wave phase mentioned above were observed after propranolol injection, too. It is concluded that pulmonary arterial pressure has a close relation to the adrenergic system.
社団法人日本循環器学会の論文
1970-10-20

体位連続変換による肺動脈圧の変動に関する研究 : 主として調和分析による研究 : 〔附〕交感神経β受容体遮断剤投与実験

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