HEMODYNAMIC EFFECTS OF BETA-ADRENERGIC BLOCKADE WITH PINDOLOL, OXPRENOLOL, PROPRANOLOL AND BUFETOLOL HYDROCHLORIDE IN ESSENTIAL HYPERTENSION

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概要

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• Hemodynamic studies (using ^<131>I-labeled albumin [RISA]) were performed before and 5 and 42 weeks after the oral administration of pindolol (av. 30 mg/day), oxprenolol (av. 216 mg/day), propranolol (av. 75 mg/day) or bufetolol hydrochloride (av. 30 mg/day) in 40 patients with essential hypertension. Responders to the antihypertensive actions of short-term (5 weeks) pindolol or bufetolol showed a reduction in total peripheral resistance (pindolol, from av. 2622 to 2022 dyne・sec・cm^<-5>・m^2; befetolol, from av. 3301 to 2620, p<0.05), without significant changes in cardiac index, while hypotensive actions of propranolol or oxprenolol appeared to be due mainly to a decrease in cardiac output (propranolol, from av. 4.03 to 2.99 L/min/m^2; oxprenolol, from av. 3.97 to 3.29 L/min/m^2), although the decrease in cardiac output was not significant. In long-term (42 weeks) oxprenolol therapy, antihypertensive effects seemed to be related to reduced cardiac output and a readaptation of peripheral resistance to chronic reduction of cardiac output was not always observed. Circulation time was determined in 9 patients with oxprenolol therapy and 8 with pindolol therapy by the measurement of the arrival time in the cerebral hemisphere of the intravenously injected radioisotope. The patients with oxprenolol therapy showed significant prolongation in circulation time (short-term administration, av. 6.6 to 8.4 sec; long-term administration, av. 6.6 to 9.2 sec, p<0.05), while no prolongation was observed in pindolol therapy. These results suggest that hemodynamic responses to beta-blocking agents are not uniform and that the antihypertensive actions of beta-blockers depend on the effects on both cardiac output and peripheral vascular resistance.

• 社団法人日本循環器学会の論文
• 1976-07-20

著者

• Matsui Yutaka

  Dept. Of Int. Med. Dept. Of 2nd Radiology

• TSUKIYAMA HISAICHIRO

  2nd Dept, of lntern. Med. , Yokohama aty Univ. Schcol of Med

• OTSUKA KEIKO

  2nd Dept, of lntern. Med. , Yokohama aty Univ. Schcol of Med

• MIYAMOTO KAZUYUKI

  2nd Dept, of lntern. Med. , Yokohama aty Univ. Schcol of Med

• HASHIMOTO MASATOSHI

  2nd Dept, of lntern. Med. , Yokohama aty Univ. Schcol of Med

• YASUTAKE SHIGEYUKI

  2nd Dept, of lntern. Med. , Yokohama aty Univ. Schcol of Med

• HORI MASAKO

  Kanagawa Prefectural Hospital Center for the Adults

• MATSUI YUTAKA

  Kanagawa Prefectural Hospital Center for the Adults

• UEDA AKIO

  Kanagawa Prefectural Hospital Center for the Adults

• TANAKA TOSHIHIKO

  Kanagawa Prefectural Hospital Center for the Adults

• YAMAMOTO YOOICHI

  Kanagawa Prefectural Hospital Center for the Adults

• Yamamoto Youichi

  Kanagawa Prefectural Hospital Center for the Adults.

• Ueda Akio

  Dept. Of Int. Med. Dept. Of 2nd Radiology

• Ueda Akio

  2nd Dept. Of Intern. Med. Yokohama Univ. School Of Med.

• Otsuka Keiko

  Department Of Cardiovascular Diseases Kanagawa Medical Center For Adults

• Otsuka Keiko

  2nd Dept Of Int. Med. Yokohama City Univ. School Of Medicine.

• Horii Masako

  Department Of Cardiovascular Diseases Kanagawa Medical Center For Adults

• Horii Masako

  Dept. Of Int. Med. Dept. Of 2nd Radiology

• Yamamoto Yooichi

  Department Of Radiology Kanagawa Medical Center For Adults

• Tanaka Toshihiko

  Dept. Of Radiotherapy Kanagawa Pref. Hospital Center For Adults

• Tsukiyama Hisaichiro

  Department Of Cardiovascular Diseases Kanagawa Medical Center For Adults

• Tsukiyama Hisaichiro

  2nd Dept Of Int. Med. Yokohama City Univ. School Of Medicine.

• Ohtsuka Keiko

  2nd Dept Of Int. Med. Yokohama City Univ. School Of Medicine.

• Ueda Akio

  The Dept. Of Intern. Med. The Center For Adult Disease

• Hoshino Masanobu

  Second Department Of Internal Medicine Yokohama City University School Of Medicine

• Otsuka Keiko

  2nd Department Of Internal Medicine Yokohama City University School Of Medicine

• Tsukiyama Hisaichiro

  2nd Department Of Internal Medicine Yokohama City University School Of Medicine

• Miyamoto Kazuyuki

  2nd Dept Of Lntern. Med. Yokohama Aty Univ. Schcol Of Med

• Yasutake Shigeyuki

  2nd Dept Of Lntern. Med. Yokohama Aty Univ. Schcol Of Med

• Hashimoto Masatoshi

  2nd Dept Of Lntern. Med. Yokohama Aty Univ. Schcol Of Med

• Tsukiyama Hisaichiro

  2nd Dept. Of Intern. Med. Yokohama Univ. School Of Med.

• Matsui Yutaka

  2nd Dept. Of Intern. Med. Yokohama City Univ. School Of Med.

• Otsuka Keiko

  Dept. Of Intern. Med. Yokohama City Univ.

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