肝硬変症その他諸疾患における換気量並びに全身酸素消費量についての病態生理学的研究 : (前編)室内空気呼吸時について

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Prof. K. HARA and his coworkers have demonstrated that distinct differences in visceral circulation and metabolism during an induced hypoxemia (by inhalating 10% O_2 gas mixture) could be observed between normal subjects and patients with visceral vascular damage. During the induced hypoxemia the splanchnic oxygen consumption was found to decrease in cirrho-tics, while it increased markedly in normal subjects. In liver cirrhosis, partial pressure of oxygen (PaO_2) decrease, pH increase, partial pressure of carbon dioxide (PaCO_2) decrease and a pat-tern of respiratory alkalosis was observed during room air breathing. This suggested that there might be some relation between these results, respiratory volume (VE) and total oxygen consumption (VO_2). Such results are not available in the literature and the present paper will attempt to clarify this relationship. Method s Measurement of VE, VO_2 and analysis of arterial blood gas were performed before and during the 10% O_2 gas inhalation. In measuring VE and VO_2, a 3 minutes' sample of expired gas, collected with the DOUGLAS bag was determined with the SCHOLANDER microgas analyzer. Arterial blood was obtained from the femoral artery through places needles, and the PaO_2 and PaCO_2 were determined with the I. L. meter (Instrumentation Laboratory U. S. A). Bicarbonate (HCO_3^-) was calculated by using the HENDERSON-HASSELBACH equation from the determined values of PaCO_2 and pH. Arterial oxygen saturation (SaO_2) was measured with the VAN SLYKE manometer or determined from the O_2 dissociation curve. Materials This study was carried out on the following table cases.
社団法人日本循環器学会の論文
1967-07-15

肝硬変症その他諸疾患における換気量並びに全身酸素消費量についての病態生理学的研究 : (前編)室内空気呼吸時について

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