Caldiac Muscle Cell Damage Through Autoimmune Mechanism : Can cardiac proteins provoke autoimmune myocarditis? : 54th Annual Scientific Session of the Japanese Circulation Society
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概要
- 論文の詳細を見る
In this paper, the ability of human cardiac myosin to provoke autoimmune myocarditis was investigated. Myosin fractions were immunized into A.SW. mice. Lewis rats or Hartley guinea pigs. All of the immunized rats displayed overt symptoms of myocarditis and, in a few cases, died from it. The hearts of these rats were enlarged and discolored. Histologically, the muscles of the heart were characterized by remarkable cell infiltration, extensive myofiber necrosis and the appearance of polynuclear giant cells. Neither mice nor guinea pigs showed such disease profile. In this novel experimental model, the disease state was transferable by T lymphocytes. Thus, cardiac myosin was shown to provoke muscle cell damage through a T cell mediated autoimmune process.
- 社団法人日本循環器学会の論文
- 1991-11-20
著者
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Kodama Makoto
Department of Cardiology, Niigata University Graduate School of Medical and Dental Sciences
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Izumi Tohru
Niigata University School Of Medicine
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Kodama Makoto
Departments Of First Internal Medicine And Immunology
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FUJIWARA MICHIO
Departments of First Internal Medicine and Immunology
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Fujiwara Michio
Department Of Immunology Institute Of Medical Science University Of Tokyo
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