副腎ステロイドホルモンの腎機能に及ぼす影響 : 尿細管電解質転送機能のStop Flow Methodによる研究
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Malvin and others developed a new method to visualize the localization of tubular reabsorption of various substances by relatively simple stop flow technique. In this paper the author presents studies on the effects of various corticosteroids on tubular transport of electrolytes and its localization by this technique. Materials and method Dogs weighing 15-10kg were divided in 6 groups. 1) Control group received intravenous drip of glucose saline for the osmotic diuresis as indicated in Malvin's technique. Drugs to be tested were dissolved in the glucose saline above cited and injected intravenously. Their doses were as following. 2) Desoxycorticosterone glucoside 1 mg/kg. 3) Hydrocortisone hemisuccinate 10mg/kg, 4) Dexamethasone phosphate 0.8mg/kg and 0.4mg/kg. 5) Single intravenous injection of 20 IU ACTH and successive injection of ACTH for 4 days (20 IU i. m., 10 IU i. m., 10 IU i. m., 20 IU i. v.) 6) Hydrochlorothiazide 10mg/kg. Na and K were determined by flame photometer, Cl by Schales & Schales, PAH by Tsuda's method, Cratinine by Jaffe's method. From each samle of all urine collections, U/P/(U/Pcr) was calculated, where U/P is the concentration ratio of urine and plasma with the tested substance and U/Pcr is that with creatinine. To illustrate the localization of the tubular reabsorption U/P/(U/Pcr) was plotted to percent volume within kidney from left (distal) to right (proximal). Results a) The patterns of control group were very similar as Pitts and others published previously. (Table I, Fig. 1) b) Hydrochlorothiazide inhibited markedly the reabsorption of Na and Cl in distal tubuli. Increased secretion of K was observed also in distal tubuli. (Table I, Fig. 2) c) D O C increased Na and Cl reabsorption in distal and proximal tubuli. Peak of K in distal tubuli was not significant. (Table I, Fig. 3)
- 社団法人日本循環器学会の論文
- 1961-07-15
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- 副腎ステロイドホルモンの腎機能に及ぼす影響 : 尿細管電解質転送機能のStop Flow Methodによる研究