肺血管における自律神経支配の研究
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There is a considerable discrepancy of opinions among different investigators as to the action of the autonomic nervous system on pulmonary blood vessels. In attempt to shed some light on this field and contribute to a fuller clinical understanding of the nature of this vascular bed, the author studied the effect of various drugs and of the electrical stimulation of the autonomic nerves on the pulmonary hemodynamics in cats with such experimental arrangements where as much as possible of the extrapulmonary factors likely to affect the pulmonary blood vessels was eliminated; the author discusses the autonomic nervous control of pulmonary blood vessels. Method s The chest of the cat was opened on the right side under a positive pressure respiration; according to the method of Burton various drugs, e. g., adrenaline, imidaline, acetylcholine and atropine, was injected directly into the pulmonary blood vessel individually or in combination ; the author severed the right cervical vagus nerve and right sympathetic trunk just beneath and above the inferior cervical ganglion and applied the electrical stimulation to the peripheral cut ends using 5-8 volts and 20 c.p.s.; changes produced by such procedures in the pulmonary blood flow were calculated. Results With adrenaline solution of 1 : 500,000 dilution, imidalin or acetylcholine injected into the blood vessel of the lungs, or with the electrical stimulation of the vagus nerve, the pulmonary blood flow was increased. With adrenaline solution of 1 : 10,000 dilution injected by the same way or immediately after the section of the vagus nerve, the pulmonary blood flow was decreased. With adrenaline solution of 1 : 100,000 dilution or atropine solution injected, or with the unilateral electrical stimulation of the inferior cervical sympathetic trunk, no marked change resulted. During the phase of decreased flow produced by the injection of adrenaline solution of 1 : 10,000 dilution, injection of acetylcholine caused the flow to be increased somewhat but still up to a level lower than in the control phase. With adrenaline solution of 1 : 10,000 dilution injected after atropin, there occurred no decrease in flow. With adrenaline injected in 1 : 10,000 dilution following an injection of imidaline, there occurred a slight decrease in flow.
- 社団法人日本循環器学会の論文
- 1961-07-15
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- 肺血管における自律神経支配の研究