実験的動脈硬化症に関する研究 : Lanolinおよび中性脂肪飼育家兎の血清脂質ならびに病理組織について
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Introduction Studies on arteriosclerosis have been under-taken by many investigators from pathological and biochemical aspects since Anitschkow et al. succeeded in inducing the experimental atheromatous plaque in the cholesterol fed rabbits. In recent years the ultracentrifugal method introduced by Gofman et al, has been in general use as the most excellent method for the study of serum lipoproteins, and by this method it has been recognized that most of the serum lipids exist in the form of lipo-proteins. In Japan, Oshima, Yasugi and their co-workers have been undertaking studies on the relationships between serum lipoproteins and the development of arteriosclerosis by means of the ultracentrifuge. They reported that increases in the levels of Sf 0-20 and Sf 20-400 Iipoprotein fractions bear the significant relationships to the development of arteriosclerosis, but that the total cholesterol level does not always have a significant relation-ship thereto. It was further reported regarding lipoprotein metabolism (1) that heparin possesses_s a lipemia-clearing activity, (2) that heparin activates lipoprotein lipase which de-composes neutral fat component of the lipoprotein into fatty acid and glycerin and (3) that heparin when injected produces a decrease in the Sf 20-400 Iipoprotein fraction and an increase in the serum cholesterol level and inhibits arteriosclerosis formation (This is not a definitive assertion). The present study has been undertaken to detect any presence of atherogenesis due to neutral fat in the rabbits, and to compare the lipid metabolisms between lanolin-fed and neutral fat-fed rabbits. Method Subjects : Male rabbits weighing 2-3kg were used and they were divided into three groups : a normal group which was placed on an ordinary diet, a lanolin-fed group was further sub-divided into two groups which consisted of the following, lanolin-fed group (3 gm of lanolin /day for a period of 90 days) and lanolin-heparin-fed group (3gm of lanolin/day and 5mg of heparin/twice a week for a period of 90 lays. Lanolin was administered larally and heparin was administered intravenously.), and a neutral fat-fed groupwhich was given by oral route 10 gm of hydrogenerated cocoanuts oil daily for a period of 150 days.
- 1961-03-15
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関連論文
- 実験的動脈硬化症に関する研究 : Lanolinおよび中性脂肪飼育家兎の血清脂質ならびに病理組織について
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- 血清Cholesterolの時間的変動および血清Total lipidと動脈硬化症との関係について : 第25回日本循環器学会総会
- 動脈硬化症に於ける血清脂質に関する研究 : heparin activated lipoprotein lipaseについて
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