心電図による交感神経切除心についての研究 (第2報) : 自律神経剤に対する反応について
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概要
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In order to study the mechanism of the accentuation of the sensibility in the denervated heart, the auther performed the bilateral cervico-thoracal sympathectomy on I 4 healthy rabbits, each weighing around 2 kg. Before and after the ganglionectomy, pharmaco-dynamic tests with adrenalin, noradrenalin, acetylcholin, pilocarpin and atropin etc. were pereformed and the changes in cardiac function were studied by means of consecutive electrocardiographic tracings. The results were as follows : (1) On each of ten rabbits, adrenalin HCl 0.02mg was injected intravenously and ECG tracings were obtained. Before the ganglionectomy the injection resulted in bradycardia in 75% of the cases and tachycardia in 25% . The bradycardia was of sinus origin, of nodal rhythm and of combined form with incomplete sino-auricular block, atrio-ventricular dissociation or bigeminia. The tachycardia was of sinus origin or nodel rhythm. By the adrenalin test after the ganglionectomy, ventricular paroxysmal tachycardia developed in two cases and the decrease 6f the cardiac rate occurred in 6 cases of which one case was of ventricular automaty, the other five cases were of sinus or nodal rhythm. In some cases incomplete sino-atria.1 block was also combined. In two cases which had the adrenalin test repeatedly on the 26th and 4lst days respectively after the ganglionectomy, an increase in the cardiac rate and nodal rhythm were observed and ventricular extrasystoles also appeared. The ST depression was observed in five cases. (2) On each of seven rabbits, noradrenalin 0.02mg was injected intravenously. Before the ganglionectomy the injection caused sinus bradycardia in all cases and after the ganglionectomy so did in all except one case of nodal rhythm. Comparing the grades of the decrease in cardiac rates by noradrenalin injection, the decrease rate seems to be lower after than before the ganglionectomy. Two cases of more than 20 post-operative days showed an ECG evidence of sino-atrial block or nodal rhythm. (3) Each of ten rabbits received acetylcholin-HCl 2 mg. Before the ganglionectomy acetylcholin injection caused an increase in the cardiac rate in all cases. After the ganglionectomy the injection caused an increase in the cardiac rate in 3 cases, a decrease in one case, alternation from the increase to de-crease in 3 cases and sino-atrial block in one case. The increase rate of heart beats seems to be larger before than after the gangalionectomy. (4) Each of nine rabbits received pilocarpin-HCl0.2 mg intravenous injection. This injection resulted in various changes in the cardiac rate, i. e. the increase, decrease and alternation from the increase to decrease etc., regardless of the ganglionectomy. (5) Each of seven rabbits received atropin
- 社団法人日本循環器学会の論文
- 1961-10-15