SKELETAL MUSCLE REVASCULARIZATION BY ARTERIAL IMPLANTATION

概要

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An experimental study on the arterial implantation in the skeletal muscles of the thigh in the dogs is presented. In an attempt to supplement the disadvantage of lack of sinusoid system and periodic contraction in the skeletal muscle, a 2 to 3mm caudad arteriovenous fistula was provided. Patency of the implanted vessel was demonstrated in 13 out of 15 dogs at 2 months follow-up examination. Arteriovenous fistulae either spontaneously closed approximately one month after implantation or were operatively closed 14 to 59 days after implantation. The implanted artery in 7 of the 11 surviving animals remained patent for 4 to 7 months after implantation and were sacrificed for histological examination. The implanted arteries showed no significant alteration of the vessel wall. Formation of anastomosis was demonstrated in these 7 animals 74 to 121 days after implantation both on angiograms and on histological sections with injections of Micropaque. It is evident that both the control of size of arteriovenous fistula and the proper time of closing the fistula are of extreme important for the success of skeletal muscle implantation. This Study gives us reason to believe that the clinical application of skeletal muscle revascularization can be expected in the future.
社団法人日本循環器学会の論文
1974-06-20