CONTRIBUTION OF CHAMBER COMPLIANCE AND LEFT VENTRICULAR MINIMUM PRESSURE TO ABNORMAL LEFT VENTRICULAR FILLING DYNAMICS
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概要
- 論文の詳細を見る
This study was designed to clarify whether changes in transmitral flow velocity patterns in left ventricular (LV) dysfunction are determined primarily by changes in left atrial (LA) pressure and LV relaxation, and, if not, to determine the contribution of changes in other parameters. Two levels of acute LV dysfunction were produced in 11 dogs by coronary microembolization, and pulsed Doppler transmitral flow velocity patterns and hemodynamic parameters were recorded. The mean ratio of peak early diastolic filling velocity (E) to peak late diastolic filling velocity decreased with mild LV dysfunction (LV end-diastolic pressure of between 12 and 17 mmHg), and redistribution of diastolic filling to early diastole was observed with severe LV dysfunction (LV end-diastolic pressure of ≥18 mmHg). Changes in E correlated best with those in the LA-LV pressure gradient integral. Multiple linear regression analysis of the changes in possible determinants of the pressure gradient integral, i.e.. LA to LV crossover pressure, LV time constant, LV minimum pressure, and LA and LV chamber compliance, yielded a highly significant correlation with the changes in E. However, analysis of only the changes in the crossover pressure and the time constant showed a very poor correlation. Thus, changes in chamber compliance and LV minimum pressure, in addition to the changes in LA pressure and LV relaxation, may significantly affect the changes in E that are associated with LV dysfunction.
- 社団法人日本循環器学会の論文
- 1993-12-20
著者
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Kitabatake Akira
Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University
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Kamada Takenobu
The First Department Of Medicine And The Department Of Medical Information Science
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Kitabatake Akira
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Kitabatake Akira
The First Department Of Medicine Osaka University School Of Medicine
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Tanouchi Jun
Osaka Acute Coronary Insufficiency Study (oacis) Group:osaka Rosai Hospital
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Tanouchi Jun
大阪労災病院 循環器科
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Kitabatake Akira
From The Division Of Cardiology First Department Of Medicine And The Department Of Pathophysiology O
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Tanouchi Jun
大阪大学 第1内科
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Kitabatake A
Hokkaido Univ. Sapporo Jpn
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HORI MASATSUGU
The First Department of Medicine, Osaka University Medical School
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Yamamoto Kazuhiro
The First Department of Internal Medicine, Osaka University School of Medicine
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TANOUCHI JUN
The First Department of Medicine, Osaka University School of Medicine
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MASUYAMA TOHRU
The First Department of Medicine, Osaka University School of Medicine
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Arai Kazutaka
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
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Kamada Takenobu
1st Dept. Of Med. Medical School Osaka University
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Kitabatake Akira
Department Of Cardicvascular Medicine Hokkaidou University
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Kitabatake Akira
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
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Tanouchi Jun
The First Department Of Medicine Osaka University Medical School
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Hori Masatsugu
The First Department Of Medicine Osaka University Medicial School
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Masuyama Tohru
The First Department Of Medicine Osaka University Medical School
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Kitabatake Akira
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
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Hori Masatsugu
The First Department Of Medicine And The Department Of Medical Information Science
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Kitabatake Akira
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of Medicine
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Kitabatake A
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Arai Kazutaka
From The Division Of Cardiology First Department Of Medicine And The Department Of Pathophysiology Osaka University School Of Medicine
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KAMADA Takenobu
the First Department of Internal Medicine, Osaka University Medical School
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