IMPAIRED MICROVASCULAR VASODILATOR RESERVE IN CHRONIC CIGARETTE SMOKERS : A Study of Post-occlusive Reactive Hyperemia in the Human Finger

概要

論文の詳細を見る
To assess the vasodilator reserve in microcirculation, post-occlusive reactive hyperemia was examined in 21 chronic cigarette smokers (mean age; 50±7 years) and 21 non-smokers (mean age; 51±6 years), who were all healthy males. Reactive hyperemia was induced by occluding the digital artery at the base of the middle finger, and the increase in skin blood flow (Δflow) was analyzed with a laser Doppler flowmeter. Occlusion time was increased in a stepwise manner from 30 sec up to 300 sec. Baseline skin blood flow was similar in both groups (smoker, 27±9ml/min/100 g; non-smoker, 25±10ml/min/100 g, NS). The Δflow in smokers was significantly less (23%-59%) than that in non-smokers. Furthermore, the reduced Δflow in smokers was inversely correlated with Brinkmann's smoking index (r=0.567, p<0.01). These results indicate that chronic cigarette smoking impairs the microvascular response to transient ischemia, and that this impairment correlates with the intensity of the smoking habit.
社団法人日本循環器学会の論文
1993-12-20