THE STROKE VOLUME IN JUVENILE BORDERLINE HYPERTENSION
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概要
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Hemodynamic changes in supine and upright position and during exercise were studied in 144 men including 37 normal subjects and 107 patients with borderline hypertension. Borderline hypertensives were classified in 4 groups, according to the basal level of heart rate and stroke index. In the first two groups, stroke index was normal, but heart rate was either decreased (Group I) or elevated (Group II): supine total peripheral resistance was superior (Group I; p < 0.02) or equal (Group II) to normal values; plasma volume was normal or slightly decreased; hemodynamic response to tilt test closely approximated the normal; impaired adaptation of cardiac index and stroke index to exercise was observed in Group II (p < 0.001). In the other two groups, stroke index was significantly elevated (p < 0.0001) but heart rate was either decreased (Group III) or increased (Group IV); supine total peripheral resistance values were decreased (p < 0.001); plasma volume was equally reduced (p < 0.001 ); abnormal percentile increase in diastolic arterial pressure (p < 0.02; p < 0.001) and total peripheral resistance during tilt test were observed; during exercise, only the patients of Group IV had an impaired adaptation of cardiac index (p < 0.001) and total peripheral resistance (p < 0.02). The study provide evidence that in boderline hypertension i) a high basal level of stroke volume is associated with a reduced plasma volume and an impaired adaptation of total peripheral resistance during tilt, ii) a high basal level of heart rate is associated with an impaired adaptation of cardiac output during exercise, and iii) only patients having an increase in both heart rate and stroke volume exhibited a specific hemodynamic pattern including: reduction of plasma volume, imparied adaptation of cardiac output during exercise, impaired adaptation of total peripheral resistance during tilt and exercise.
- 社団法人日本循環器学会の論文
- 1975-05-20
著者
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London G.m.
Laboratoire D'hemodynamique Du Centre De Recherche De I'hypertension Arterielle
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Milliez P.l.
Laboratoire D'hemodynamique Du Centre De Recherche De I'hypertension Arterielle
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SAFAR M.E.
Laboratoire d'Hemodynamique du Centre de Recherche de I'Hypertension arterielle
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WEISS Y.A.
Laboratoire d'Hemodynamique du Centre de Recherche de I'Hypertension arterielle
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Weiss Y.a.
Laboratoire D'hemodynamique Du Centre De Recherche De I'hypertension Arterielle
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Safar M.e.
Laboratoire D'hemodynamique Du Centre De Recherche De I'hypertension Arterielle