HEMODYNAMIC AND METABOLIC EFFECTS OF ACTIVITIES OF THE ADRENERGIC BETA RECEPTOR IN PHYSICAL EXERCISE
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The hemodynamic and metabolic effects of β-adrenergic blockade by the use of propranolol has been studied to clarify the physiological significance of β-adrenergic receptor activities during exercise in man and animals. Seven healthy men and twelve thyrotoxic patients were the subjects in this study. All these subjects were examined on bicycle ergometer at a moderate work load for 10 min. in a supine position. No significant changes of hemodynamic parameter induced by P. was observed in healthy men, but in patients group, significant decrease of systolic blood pressure and heart rate were observed at rest. Inhibitory effects of P. on heart rate, systolic blood pressure and cardiac work (M.T.T.I.) were marked during exercise in both group. A11 the metabolic effects including oxygen consumption, plasma pyruvate, lactate and XL production were suppressed with P. in both groups. Mobilization of NEFA induced by exercise were also modified, but plasma glucose was kept invariable during the experimental course. Oxygen debt showed a slight increasing tendency in both groups after P. adm. But the changes were not remarkable. Moreover, in attemt to analyze more precisely these metabolic changes in exercising time, author had animal experiments using rats and made exercise test. In rats treated with P., the plasma lactate concentration did not so increase and the glycogen contents in skeletal and heart muscle were not reduced by swimming exercise probably due to blocking on the activation of phosphorylase. But it was found invariably to reduce the glycogen contents in the liver regadress of pretreatment with P. Plasma NEFA in animals showed the similar pattern to that of man, but no marked triglyceride changes in heart and epididymal fat pad were observed. For the purpose of investigating whether β-receptor has any influence on the disappearance rate of lactate, author infused 1 mol of L(+) sodium lactate at the rate of 9 mg/kg/min into the femoral vein of 8 anesthetized dogs, the plasma lactate concentration in a arterial blood was measured at a constant time interval before and after P. adm. It has been demonstrated that P. promote the disappearance rate of lactate from blood in this experiment. It is concluded that β-adrenergic receptor play an important role on the hemodynamic and the metabolic changes to muscular exercise and the mechanisms have been discussed.
- 社団法人日本循環器学会の論文
- 1973-05-20
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- HEMODYNAMIC AND METABOLIC EFFECTS OF ACTIVITIES OF THE ADRENERGIC BETA RECEPTOR IN PHYSICAL EXERCISE