Effects of Hereditary and Environmental Factors on Development of Myocardial Infarction

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To study hereditary and environmental factors on the development of myocardial infarction, five hundred and thirty men and wemen with myocardial infarction were compared with an age and sex-matched series of 530 healthy subjects. 1. A much greater incidence of myocardial infarction was noted when one or more among parents and sibling had a history of hypertension, apoplexy, ischemic heart disease or sudden death than when neither parents nor sibiling suffered from these disease. 2. Combinations of two factors - (1) heredity and hypercholestermeia, (2) hypertension, and hypercholesteremia, (3) cigarette smoking and hypercholesteremia, (4) diabetes mellitus and hypercholesteremia revealed a marked range of risk. 3. The persons classified in managerial, professional and clerical occupation had a much higher incidence rate than those in the other occupations. 4. The dietary habits of excessive intake in total fats, sugar, and salt were correlated significantly to the development of acute myocardial infarction. 5. There was a significantly increased incidence of acute myocardial infarction on snowy day, cold weather and sudden changes in temperature. 6. The highest monthly incidence was Descember and the lowest was Auguts. The seasonal difference became less and less.
1973-04-20