An Experiment of Prophylactic Medication for Those with Mild Hypertension in Population : A Controlled Study on 1500 Cases

概要

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A double blind population study of preventive antihypertensive medication was carried out as a more active way of the control of mild cases. The administration of 0.1 mg of reserpine plus 12.5 mg of hydroflume-thiazide daily was carried out safely for three months, resulting in significant blood pressure fall. During one year follow up there-after, 1 6 per cent of those treated and 1 2 per cent of the placebo group always maintained a lower blood pressure compared with their original state. Three cases of apoplectic accident occurred in the placebo group (3/408. 0.8 per cent), and none in the treated (0/426). The side effects of medication were slight and rare. The rebound phenomena were not observed. Under careful examination such preventive medication is applicable effectively at mass control for hypertension.
社団法人日本循環器学会の論文
1965-09-20