Significance of Venous Return of Development of Pulmonary Edema

概要

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From the pulmonary edema experimentally induced with epinephrine, authors have stated that increased venous return and reduced cardiac output, the latter is due to a suppressed cardiac function, are largely responsible for production of the pulmonary edema. The pressor action of epinephrine would be considered as one of the determinant factors. If so, epinephrine would be replaced with angiotensin for producing pulmonary edema. This is not a case, however, because of absence of an accelerating influence on the venous blood flow in angiotensin, in spite of the fact that epinephrine has a potent effect on the venous system through the autonomic nervous system. When these pressor substances are given to the animals subjected to the total ablation of baroreceptor nerves, the state of affairs is quite reverse; it is rather difficult to produce the pulmonary edema with epinephrine, but readily with angiotersin. This has suggested significance of the autonomic nervous system on the regulation of the venous return.
社団法人日本循環器学会の論文
1965-04-20