家兎の実験的動脈硬化症に及ぼすビタミンB_6活性型の影響について

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Purpose Since Rinehart has succeeded to cause arteriosclerosis in monkeys by administration of B_6 deficient diet, many studies on the relationship between B_6 and arteriosclerosis have been reported. Recently in our clinic, it was succeeded to cause arteriosclerosis in B_6 deficient monkeys. Many factors to cause arteriosclerosis have been considered but they have not been clarified yet. However, it is supposed that metabolic disturbances of the high energy phosphate due to B_6 deficiency may accelerate the occurrence of arteriosclerosis. Since Hahn has reported the relationship between Lipemia Clearing Factor (LCF) and arteriosclerosis, many similar studies have been reported. In one of them, it was reported that LCF was decreased by B_6 deficiency and could be restored by the administration of pyridoxal phosphate (PAL-P). It may suggest there is a close relationship between B_6 (active form) and LCF. Considering of these observations, the author has studied the effect of B_6 on the experimental arteriosclerosis in rabbits. Method s Both preventive and therapeutical experiments were performed. Preventive experiment : Pyridoxine (PIN), PAL-P or pyridoxamine phosphate (PAM:-P) (respectively 10mg/day) was injected, while administering lanolin in rabbits. The data were compared with those of the noninjected control group. Therapeutic experiment : 1) In rabbits, which were made arteriosclerotic by lanolin administration for 1 6 weeks, PIN, PAL-P or PAM-P was injected and usual diet was given for 1 2 weeks. And the data were compared with those of the noninjected group. 2) In rabbits, which were made arteriosclerotic by the same procedure, the effects of the combined treatment with PIN or PAL-P injection and lanolin feeding for 12 weeks were studied. In the above experiments, serum total cholesterol and phospholipids were determined and then, the animals were killed after 12 weeks and investigated histologically.
社団法人日本循環器学会の論文
1963-05-20

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