Angiotensin II Type 1 Receptor Gene Adenine/Cytosine^<1166> Polymorphism is not Associated With Mitral Valve Prolapse Syndrome in Taiwan Chinese
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概要
- 論文の詳細を見る
The adenine/cytosine^<1166> (A/C^<1166>) polymorphism of the angiotensin-II type 1 receptor (AGTR1) gene is presumed to be associated with mitral valve prolapse syndrome (MVPS) in Caucasians. To investigate whether a similar association exists among the Chinese population in Taiwan, 100 patients with MVP diagnosed by echocardiography and 100 normal subjects were studied by polymerase chain reaction-based restriction analysis. The difference in genotype (χ^2=0.24 ; p=0.89) and allelic (Yates' χ^2=0.06 ; p=0.81) frequencies between the groups were not significant. Further categorization of the MVP patients unto mild and severe subgroups also revealed no statistical difference from the controls. It was concluded that A/C^<1166> polymorphism of the AGTR1 gene is not a suitable genetic marker of MVPS in Taiwan Chinese.
- 社団法人日本循環器学会の論文
- 2002-01-20
著者
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Shi Yi-ru
Department Of Pediatrics And Medical Genetics China Medical College Hospital
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Shi Yi-ru
Department Of Medical Research China Medical College Hospital
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TSAI Fuu-Jen
Department of Medical Research, China Medical College Hospital
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Chou Hsiang-Tai
Division of Cardiology, Department of Medicine
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Wu Jer-Yuarn
Department of Pediatrics and Medical Genetics, China Medical College Hospital
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Wu Jer-yuarn
Department Of Pediatrics And Medical Genetics China Medical College Hospital
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Wu Jer-yuarn
Department Of Medical Genetics China Medical College Hospital
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Tsai Fuu-jen
Department Of Pediatrics And Medical Genetics China Medical College Hospital
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Chou Hsiang-tai
Division Of Cardiology Department Of Medicine
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Tsai Fuu-jen
Department Of Medical Research China Medical College Hospital
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