Histopathological Study on the Effects of Aging in Myocardium of Hypertrophied Hearts : SYMPOSIUM ON LONG-TERM MYOCARDIAL CHANGES IN HEART DISEASES : 49th Annual Scientific Session of the Japanese Circulation Society
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概要
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To clarify the effects of aging in myocardium of hypertrophied hearts, 555 autopsied hearts were studied histopathologically. Degrees of myocyte hypertrophy, disarrangement and fibrosis and lipofuscin deposits were estimated light-microscopically in tissue specimens taken from the anterior wall of the left ventricle. Myocyte hypertrophy was assigned to one of four classes from 0 to 3+ according to size. Other findings were estimated using the conventional three classes. All cases were divided according to heart weight, into the following groups : severe hypertrophy (Group I ; more than 450 g for males and 400 g for females), mild hypertrophy (Group II ; 450 > HW > 350 g for males and 400 > HW > 300 g for females) and no hypertrophy (Group III : less than 350 for males and 300 g for females). Lipofuscin deposits increased with aging, but in Group I the increase was delayed in comparison to that in other groups. As a rule, myocyte size in the outer layer was equal to or smaller than that in the inner layer (outer-layer-selective atrophy). This was particularly true in pressure-overloaded hypertrophy and less so in volume-overloaded hypertrophy. Myocyte disarrangement was observed n the inner and median layers in the oldest group. Peri-vascular fibrotic process was accelerated in hypertrophied myocardium. As to the mode of hypertrophy, aging appears to result in a kind of myocardial asymmetry of layer-selective atrophy. Fhis atrophy may be the result of an unequal distribution of myocyte disarrangement, causing unregressed hypertrophy and the development of fibrosis resulting from wear and tear of the support system against persistent mechanical stress in the overloaded myocardium.
- 社団法人日本循環器学会の論文
- 1986-10-20
著者
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Teragaki Masakazu
The First Department Of Pathology Juntendo University Medical School
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OKADA RYOZO
The Research Laboratory for Cardiovascular Pathology, Juntendo University Medical School
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FUKUDA YOSHIRO
The First Department of Pathology, Juntendo University Medical School
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Okada Ryozo
The Research Laboratory For Cardiovascular Pathology Juntendo University Medical School
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Fukuda Yoshiro
The First Department Of Pathology Juntendo University Medical School
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