EFFECTS OF INSULIN ON PRESSOR RESPONSIVENESS AND BAROREFLEX FUNCTION IN DIABETES MELLITUS

概要

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The effects of insulin on pressor responsiveness to α agonist (phenylephrine) and angiotensin II, and baroreflex function were studied in fifteen diabetic patients without autonomic neuropathy. The dose of phenylephrine required to increase systolic pressure by 25 mmHg (PD_<25>) was significantly increased from 38 ± 7 to 62 ± 9 μg (p < 0.05) after IV injection of 4 U of Actrapid monocomponent insulin. The dose of angiotensin II required to increase systolic pressure by 30 mmHg (AD_<30>) was also increased from 0.29 ± 0.07 to 0.48 ± 0.10 μg (p < 0.01). Following insulin administration, the dose-response curves for phenylephrine and angiotensin II were shifted to the right. The baroreflex sensitivity was not affected by insulin. In contrast, there was no significant change in PD_<25>, AD_<30> or baroreflex sensitivity after the injection of saline. These results suggest that insulin attenuates the pressor responsiveness to α agonist and angiotensin II, which may be one of the significant mechanisms in insulin-induced vasodilation.
社団法人日本循環器学会の論文
1986-10-20