CIRCULATORY EFFECT OF SEVERAL CEREBRAL CIRCULATORY DRUGS IN MAN, WITH SPECIAL REFERENCE TO AMINOPHYLINE, PAPAVERINE, CYCLANDELATE, VINCAMINE, PROSTAGLANDIN E_1 AND ISOXSUPRINE

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Circulatory effects of several circulatory drugs, aminophylline, papaverine, cyclandelate, vincamine, prostaglandin E_1 and isoxsuprine, on cerebral blood flow (blood flow in the internal carotid artery), brachial blood flow, heart rate and systolic blood pressure were investigated by means of the on-line Doppler ultrasonic technique in 33 apparently healthy males over 60 years of age, simultaneously and continuously in situ. (1) A biphasic cerebral blood flow response was induced by intravenous aminophylline, i.e., conspicuous and sustained decrease of blood flow from during to a short time after the administration, and conspicuous but transient increase of blood flow around 1 to 2 minutes after the administration. (2) A conspicuous but transient increase of cerebral blood flow was induced by intravenous papaverine. (3) A moderate or conspicuous and prolonged increase of cerebral blood flow was induced by intravenous cycladelate and vincamine. (4) Alteration of cerbral blood flow varied with intravenous prostaglandin E_1 as follows. (i) No alteration of blood flow --4 subjects. (ii) Slight decrease or increase of blood flow--2 subjects each. (5) No alteration or slight increase of cerebral blood flow was induced by intramuscular isoxsuprine. (6) The findings coincide well with those obtained previously.
社団法人日本循環器学会の論文
1978-05-20