THE CHRONIC EFFECT OF NITRENDIPINE ON HEART AND REGIONAL BLOOD FLOW IN RENOVASCULAR HYPERTENSIVE RATS

概要

論文の詳細を見る
Nitrendipine, a new calcium entry blocker, was administered to renovascular hypertensive rats (2KlC Goldblatt) (RHR, n=8) and sham operated control rats (ShC, n=8) to evaluate the effects on left ventricular hypertrophy and regional blood flow using radioactive microspheres. Nine untreated RHR and 8 untreated ShC served as control groups. After 6 weeks treatment (20 mg/kg subcutaneously, every other day), blood pressure reduced significantly in both RHR and ShC associated with a reduction in total peripheral resistance. Significant reversal of left ventricular hypertrophy was noted in RHR (1278±41 to 1024±19 mg, p<0.01), but not in ShC. There was a significant relationship between blood pressure and left ventricular mass in both untreated rats (r=0.955, p<0.001) and treated rats (r=0.729, p<0.005). Nitrendipine increased coronary blood flow in RHR (430±30 to 566±47 ml/m/100g, p<0.05) as well as in ShC (375±15 to 508±29 ml/m/100g, p<0.05), without increasing cardiac oxygen demand. Renal blood flow was unchanged, whereas cerebral blood flow was significantly increased in both RHR (128±6 to 164±13 ml/m/100g, p<0.01) and ShC (124±7 to 173±5 ml/m/100g, p<0.01). Thus, long treatment of nitrendipine effectively regressed cardiac hypertrophy toward normal. Nitrendipine reduced total peripheral resistance; however, the effects on regional blood flow were not uniform among various organs.
社団法人日本循環器学会の論文
1987-09-20