PROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE AGAINST OXYGEN TOXICITY IN RAT'S HEART LUNG PREPARATION
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概要
- 論文の詳細を見る
Oxygen toxicity in the non-ischemic and non-hypoxic heart has not been reported. In an experiment on isolated rat heart lung preparation, the effects of superoxide dismutase (SOD) on oxygen toxicity during hyperoxic perfusion were evaluated with intramyocardial high energy phosphates and the release of creatine phosphokinase (CPK) in the perfusate blood. Although there were non significant differences in high energy phosphates between SOD-treated and untreated hearts, the CPK release from the SOD-treated hearts was significantly less than from the untreated hearts. SOD increased the oxygen pressure of perfusate blood, too. These results indicate that hyperoxia induced cardiac and lung cell damage which was protected by SOD.
- 社団法人日本循環器学会の論文
- 1987-09-20
著者
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KUMAZAWA TERUO
Department of Anesthesia, Tokyo Medical and Dental University
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Kumazawa Teruo
Department Of Anesthesia Tokyo Medical And Dental University
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Kumazawa Teruo
Department Of Anesthesiology Yamanashi Medical College
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KASHIMOTO Satoshi
Department of Anesthesiology, Faculty of Medicine, University of Yamanashi,
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Kashimoto Satoshi
Department Of Anesthesiology Faculty Of Medicine University Of Yamanashi
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Kashimoto Satoshi
Department Of Anesthesiology Yamanashi Medical College
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