PARATHYROIDS, THYROID AND DEVELOPMENT OF HYPERTENSION IN SHR

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概要

• 論文の詳細を見る

• Parathyroid glands play a significant role in the development of hypertension in spontaneously hypertensive rat (SHR), like in deoxycorticosterone acetate (DOCA) + NaCl model. Parathyroidectomy (PTX) performed after weaning delayed systolic blood pressure (SBP) increase and slowed heart rate (HR) in SHR for 42 weeks. These changes could not be attributed to decrease of serum calcium in PTX animals since supplementation of calcium, rendering serum calcium normal, did not reestablish SBP and HR to those of sham SHR. Moreover, in the thyroparathyroidectomized (TPTX) animals SBP and HR were increased by autotransplantation of parathyroids. When hypertension was established (week 15), PTX produced no more changes on cardiovascular parameters measured. These data clearly indicate that independent of thyroidectomy, PTX leads to a lesser degree of hypertension in young SHR, but was without effect on established hypertension. In conclusion, parathyroid glands are required for total development of the hypertensive process in SHR.

• 社団法人日本循環器学会の論文
• 1981-11-20

著者

• Pernot Fanny

  Laboratoire De Physiologie Era 787 Faculte De Plarmacie Universite Louis Pasteur

• BERTHELOT Alain

  Laboratoire de Physiologie Pharmacologie - Nutrition Preventive Experimentale, Universite de Franche

• SCHLEIFFER RENE

  Laboratoire de Physiologie, ERA 787, Faculte de Plarmacie, Universite Louis Pasteur

• GAIRARD ALEXIS

  Laboratoire de Physiologie, ERA 787, Faculte de Plarmacie, Universite Louis Pasteur

• Berthelot Alain

  Laboratoire De Physiologie Era 787 Faculte De Plarmacie Universite Louis Pasteur

• Gairard Alexis

  Laboratoire De Physiologie Era 787 Faculte De Plarmacie Universite Louis Pasteur

• Schleiffer Rene

  Laboratoire De Physiologie Era 787 Faculte De Plarmacie Universite Louis Pasteur

関連論文

• Combined intervention of dietary soybean proteins and swim training : effects on bone metabolism in ovariectomized rats
• PARATHYROIDS, THYROID AND DEVELOPMENT OF HYPERTENSION IN SHR
• Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats

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