THE EFFECT OF REGIONAL MYOCARDIAL ISCHEMIA ON SERIES ELASTIC AND CONTRACTILE ELEMENTS OF GLYCERINATED HEART MUSCLE IN DOGS

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概要

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• The response of the contractile and the series elastic elements to ischemia was studied with isometric contraction and quick release methods after measuring the passive length-tension relationship in glycerinated heart muscle fibers of dogs at resting state. Myocardial infarction was induced by ligating left coronary artery. Muscle fibers taken from the ischemic area three hours after ligation demonstrated reduction in maximal developed tension (P_0), the maximal rate of tension development (dp/dt_<max>) and V_<max>. The time to peak tension (t_0) was increased. As in fresh papillary muscle the modulus of elasticity of active glycerinated muscle increased in proportion to load. The stiffness of the series elastic element elevated significantly in ischemic muscle fibers. The passive stiffness in resting state showed a decrease in the slope accompanied by an increase in the intercept in ischemic heart muscle. Therefore, increased stiffness of the series elastic element and diminished contractility are present following acute myocardial infarction.

• 社団法人日本循環器学会の論文
• 1980-07-20

著者

• Bing Richard

  The Huntington Institute Of Applied Medical Research And The Huntington Memorial Hospital Pasadena T

• Maruyama Yukio

  The Huntington Institute Of Applied Medical Research And The Huntington Memorial Hospital Pasadena T

• FISCHER RENATE

  the Huntington Institute of Applied Medical Research and the Huntington Memorial Hospital, Pasadena,

• Fischer Renate

  The Huntington Institute Of Applied Medical Research And The Huntington Memorial Hospital Pasadena T

関連論文

• THE EFFECT OF REGIONAL MYOCARDIAL ISCHEMIA ON SERIES ELASTIC AND CONTRACTILE ELEMENTS OF GLYCERINATED HEART MUSCLE IN DOGS

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