Cyclic AMP and Cyclic GNP in Ischemic Myocardium and Effect of Propranolol on These Nucleotides : English Summaries of Original Articles written in Japanese

概要

論文の詳細を見る
Twenty-six mongrel dogs were sacrificed for the experiment of acetylcholine administration, and sixty-one mongrel dogs were for the experiment of acute myocardial infarction. The concentration of myocardial c-AMP and c-GMP were determined by a radioimmunoassay. By this acetylcholine adntinistration experiment, it was found that c-GMP was closely associated with the vagal nerve. The concentration of c-AMP was increased in myocardial infarcted area and non-myocardial infarcted area at 1 hour after the coronary artery ligation due to increased tone of the sympathetic nerve. The concentration of c-GMP was increased in myocardial infarcted area at 15 minutes after the coronary artery ligation due to increased tone of the vagal nerve, but this concentration was suppressed after 1 hour due to gradual accumulation of acid products in the advance of anoxia. Therefore, the ratio of cyclic AMP to cyclic GMP was increased at I hour after the coronary artery ligation, and this increased ratio was related with the induction of ventricular arrhythmia. As propranolol suppressed this increeased ratio, this drug was useful not only for the therapy of acute myocardial infarction but also for the protection of it.
社団法人日本循環器学会の論文
1980-12-20