INFLUENCE OF THE INTRARENAL BARORECEPTOR ON RENIN RELEASE DURING ACUTE RESPIRATORY ACIDOSIS IN DOG
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概要
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The role of the renal vascular baroreceptor mechanism in the renin response elicited by acute respiratory acidosis was studied in 8 chloralose anesthetized dogs. Ventilation with 8% CO_2 in air for 10 minutes (constant minute ventilation) resulted in a significant increase (P <0.01) in plasma renin activity (PRA) with a small, but insignificant, decrease in mean arterial pressure and increase in renal blood flow. The smooth muscle relaxant, papaverine, was infused into the renal artery (2 mg/min) to produced renal vasodilation and thus inhibit the renal vascular receptor for renin release. During intrarenal papaverine, the renin response to 8% CO_2 inhalation was attenuated (P < 0.05) even though blood pressure fell (P < 0.01) by an average of 21 mmHg. The data indicated that the renin response during acute respiratory acidosis is papaverine sensitive and is mediated in part by the renal vascular baroreceptor mechanism.
- 社団法人日本循環器学会の論文
- 1979-07-20
著者
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ZEHR John
Department of Physiology and Biophysics, University of Illinois at Urbana-Champaign
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Fujii Hideo
Department of Internal medicine, Yamaguchi University School of Medicine
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Zehr John
Department Of Physiology And Biophysics University Of Illinois At Champaigh-urbana Illinois.
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KURZ KENNETH
Present Address
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Kurz Kenneth
Present Address: Harry S. Truman Memorial Veterans Hospital Research Services (151)
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Fujii Hideo
Department Of Internal Medicine Yamaguchi University School Of Medicine
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- EFFECTS OF INTRARENAL PAPAVERINE INFUSION ON RENIN RELEASE DURING ACUTE RESPIRATORY ACIDOSIS IN DOGS WITH A DENERVATED AND NONFILTERING KINDEY : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- INFLUENCE OF THE INTRARENAL BARORECEPTOR ON RENIN RELEASE DURING ACUTE RESPIRATORY ACIDOSIS IN DOG
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- THE EFFECT OF BETA ADRENERGIC RECEPTOR BLOCKADE ON THE RENIN RESPONSE TO RESPIRATORY ACIDOSIS
- THE EFFECTS OF RESPIRATORY ACIDOSIS ON PLASMA RENIN ACTIVITY IN THE DOG